반응식
[C:1]1(SC)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:9]1([O:15]C)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[CH2:17]([SH:20])[CH2:18]S.N[C@H:22](C(O)=O)CC(=O)O.NCC(O)=O.N[C@H](C(O)=O)CCSC.N[C@H](C(O)=O)CC1C=CC(O)=CC=1.N[C@H](C(O)=O)CC1C=CC=CC=1.[CH3:69][S:70][CH2:71][CH2:72][C@H:73]([NH:122][C:123]([C@@H:125]([NH:138][C:139]([C@@H:141]([NH2:146])[CH2:142][C:143]([OH:145])=[O:144])=[O:140])[CH2:126]C1C=CC(OS(O)(=O)=O)=CC=1)=[O:124])[C:74]([NH:76][CH2:77][C:78]([NH:80][C@H:81]([C:92]([NH:94][C@H:95]([C:100]([NH:102][C@H:103]([C:108]([NH:110][C@H:111]([C:119]([NH2:121])=[O:120])[CH2:112]C1C=CC=CC=1)=[O:109])[CH2:104][C:105]([OH:107])=[O:106])=[O:101])CCSC)=[O:93])[CH2:82][C:83]1[C:91]2[C:86](=[CH:87][CH:88]=[CH:89][CH:90]=2)[NH:85][CH:84]=1)=[O:79])=[O:75]>>[NH2:146][C@H:141]([C:139]([NH:138][C@H:125]([C:123]([NH:122][C@H:73]([C:74]([NH:76][CH2:77][C:78]([NH:80][C@H:81]([C:92]([NH:94][C@H:95]([C:100]([NH:102][C@H:103]([C:108]([NH:110][C@H:111]([C:119]([NH2:121])=[O:120])[CH2:112][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)=[O:109])[CH2:104][C:105](=[O:106])[OH:107])=[O:101])[CH2:18][CH2:17][S:20][CH3:22])=[O:93])[CH2:82][C:83]1[C:91]2[C:86](=[CH:87][CH:88]=[CH:89][CH:90]=2)[NH:85][CH:84]=1)=[O:79])=[O:75])[CH2:72][CH2:71][S:70][CH3:69])=[O:124])[CH2:126][C:12]1[CH:11]=[CH:10][C:9]([OH:15])=[CH:14][CH:13]=1)=[O:140])[CH2:142][C:143](=[O:144])[OH:145]참가 물질
10
실험 절차
The cleavage yield of CCK-8 peptide, using a similar procedure with scavengers (thioanisole, anisole and 1,2-ethanedithiol) present in the cleavage cocktail, was about 95%. AAA showed a composition of: Asp 2.03, Gly 1.04, Met 1.92, Tyr 0.99, Phe 1.02, which is characteristic of CCK-8.
출처 및 근거
- ORD 기록
- ord-78eed412d5a6423db2dc1185692fcbc0
- 출처 데이터셋
- uspto-grants-1994_04
- 특허 번호
- US05306562
연결된 노트
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