Hydrochloric Acid → Potassium 8-(p-chlorophenylsulfonamido)-4-[3-(3-pyridyl)-2-propenyl]octanoate

HRID 1494105노트

반응식

HRID 1494105 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH:16]([CH2:23][CH:24]=[CH:25][C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)[CH2:17][CH2:18][C:19]([O:21]C)=[O:20])(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl.CC(C)([O-])C.[K+:38]>O1CCOCC1.[OH-].[Na+].C(O)(C)(C)C.O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH:16]([CH2:23][CH:24]=[CH:25][C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)[CH2:17][CH2:18][C:19]([O-:21])=[O:20])(=[O:9])=[O:10])=[CH:6][CH:7]=1.[K+:38]

참가 물질

8

반응물 3

HCID 313Hydrochloric AcidHCID 23665647Potassium tert-butoxideHCID 54073742Methyl 8-(p-chlorophenylsulfonamido)-4-[3-(3-pyridyl)-2-propenyl]octanoate

생성물 1

HCID 67916594Potassium 8-(p-chlorophenylsulfonamido)-4-[3-(3-pyridyl)-2-propenyl]octanoate

시약·촉매·용매 4

HCID 6386tert-Butanol용매HCID 8028Tetrahydrofuran용매HCID 14798Sodium Hydroxide용매HCID 312751,4-Dioxane용매

실험 절차

A mixture of 0.097 g of methyl 8-(p-chlorophenylsulfonamido)-4-[3-(3-pyridyl)-2-propenyl]octanoate in 1 mL dioxane and 0.45 mL 1N sodium hydroxide is stirred at room temperature for 18 hours. The mixture is acidified with 0.45 mL of 1N hydrochloric acid and then subjected to evaporation. The residue is triturated with methylene chloride and the organic phase is dried, filtered and evaporated to yield a light amber oil. The oil is dissolved in 1 mL t-butanol and one equivalent of potassium t-butoxide in tetrahydrofuran is added. The mixture is freeze-dried to obtain potassium 8-(p-chlorophenylsulfonamido)-4-[3-(3-pyridyl)-2-propenyl]octanoate as about a 1:1 mixture of cis and trans isomers.

후처리

  1. customsubjected to evaporation
  2. customThe residue is triturated with methylene chloride
  3. customthe organic phase is dried
  4. filtrationfiltered
  5. customevaporated
  6. customto yield a light amber oil
  7. customThe mixture is freeze-dried

출처 및 근거

ORD 기록
ord-1e7de318b8c34b9aac3b9f27dd4bcc80
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05025025

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