Hydrochloric Acid → 2-Amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile

HRID 1501265노트

반응식

HRID 1501265 반응식
[C:1](#[N:5])[CH2:2][C:3]#[N:4].[H-].[Na+].[CH2:8]=[C:9]1[O:13][C:11](=[O:12])[CH2:10]1.Cl>O1CCCC1>[NH2:4][C:3]1[O:13][C:9]([CH3:8])=[CH:10][C:11](=[O:12])[C:2]=1[C:1]#[N:5]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8010MalononitrileHCID 12661DiketeneHCID 24758Sodium hydride

생성물 1

HCID 114805352-Amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of malononitrile (3.3 g, 50 mmol) in 100 ml of anhydrous tetrahydrofuran was added sodium hydride (60%, 2.2 g, 55 mmol) at −10° C. The resulting reaction mixture was stirred for 2 hours. Then diketene (4.2 g, 50 mmol) was added dropwise to the solution. The reaction mixture was allowed to warm to room temperature and continued to stir for 30 minutes. The mixture was neutralized with hydrochloric acid, and then concentrated to give crude product as red solid, which was used in the next step without further purification.

후처리

  1. customThe resulting reaction mixture
  2. stirringto stir for 30 minutes
  3. concentrationconcentrated
  4. customto give crude product as red solid, which
  5. customwas used in the next step without further purification

출처 및 근거

ORD 기록
ord-abba68ae478945f39d9260bfa1a39571
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206128B2

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