Hydrochloric Acid → 1,2-Diamino-4-(pyrimidin-2-ylthio)benzene

HRID 1580960

반응식

HRID 1580960 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([S:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[CH:5]=[CH:4][C:3]=1[N+:15]([O-])=O.Cl.C(=O)(O)[O-].[K+]>C(Cl)(Cl)Cl>[NH2:15][C:3]1[CH:4]=[CH:5][C:6]([S:8][C:9]2[N:10]=[CH:11][CH:12]=[CH:13][N:14]=2)=[CH:7][C:2]=1[NH2:1]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 516893Potassium BicarbonateHCID 214827752-Nitro-5-[(pyrimidin-2-yl)sulfanyl]aniline

생성물 1

HCID 214827791,2-Diamino-4-(pyrimidin-2-ylthio)benzene

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

3.5 G. of 2-amino-1-nitro-4-(pyrimidin-2-ylthio)benzene is treated with 16 g. stannous chloride in 16 ml. concentrated hydrochloric acid on the steam bath for 30 minutes. The mixture is cooled, treated with an excess of potassium bicarbonate, chloroform, and filtered. The chloroform layer is dried and stripped yielding 1,2-diamino-4-(pyrimidin-2-ylthio)benzene which may be recrystallized from benzene.

후처리

  1. temperatureThe mixture is cooled
  2. filtrationfiltered
  3. dry with materialThe chloroform layer is dried

출처 및 근거

ORD 기록
ord-b1c761c4e7bf4b47a96937df1431a9ef
출처 데이터셋
uspto-grants-1976_01
특허 번호
US03935209

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