Propylamine → (1-Phenylpentan-2-yl)(propyl)amine

HRID 1588093노트

반응식

HRID 1588093 반응식
[CH2:1]([C:8]([CH2:10][CH2:11][CH3:12])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:13]([NH2:16])[CH2:14][CH3:15].[Cl-].[Ca+2].[Cl-].[BH4-].[Na+]>C1C=CC=CC=1.CO.O>[CH2:13]([NH:16][CH:8]([CH2:10][CH2:11][CH3:12])[CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:14][CH3:15]

참가 물질

8

반응물 4

HCID 7852PropylamineHCID 811881-Phenyl-2-pentanoneHCID 4311764Sodium borohydrideHCID 5284359Calcium Chloride

생성물 1

HCID 10262369(1-Phenylpentan-2-yl)(propyl)amine

시약·촉매·용매 3

HCID 241Benzene용매HCID 887Methanol용매HCID 962Water용매

실험 절차

11.0 g (0.068 mole) of benzyl-propyl-ketone are dissolved in 110 ml of benzene, whereupon 8.0 g (0.135 mole) of n-propyl-amine and 22.6 g (0.2 mole) of anhydrous calcium chloride are added to the solution. The reaction mixture is stirred at 40°-50° C. for 6 hours, then filtered and evaporated. The crude ketimine thus obtained is dissolved in 120 ml of methanol, whereupon 6.4 g (0.17 mole) of sodium borohydride are added. The reaction mixture is allowed to stand, whereupon it is poured into 500 ml of water and extracted five times with 100 ml of benzene each. The benzene solution is dried and evaporated. The crude N-propyl-1-phenyl-2-pentylamine thus obtained is purified by distillation in vacuo. B.p.: 112°-120° C./7 Hgmm, n20D =1.5030.

후처리

  1. additionare added to the solution
  2. filtrationfiltered
  3. customevaporated
  4. customThe crude ketimine thus obtained
  5. additionare added
  6. extractionextracted five times with 100 ml of benzene each
  7. dry with materialThe benzene solution is dried
  8. customevaporated

출처 및 근거

ORD 기록
ord-7b014c98301d4471b32a4fb4be330de4
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05220068

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