Chloroform → 2-(4-Acetylphenoxy)-2-methylpropionic acid

HRID 1605118

반응식

HRID 1605118 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[OH-:11].[Na+].C(Cl)(Cl)Cl>CC(C)=O>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([O:1][C:5]([CH3:6])([CH3:4])[C:8]([OH:10])=[O:11])=[CH:3][CH:4]=1)(=[O:10])[CH3:9]

참가 물질

5

반응물 3

HCID 6212ChloroformHCID 74694'-HydroxyacetophenoneHCID 14798Sodium Hydroxide

생성물 1

HCID 1041062-(4-Acetylphenoxy)-2-methylpropionic acid

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

2-(p-Acetylphenoxy)-2-methylpropionic acid was prepared from 545 g. of p-hydroxyacetophenone, 960 g. of sodium hydroxide and 715 g. of chloroform in 11 liters of acetone according to the procedure described above in Example 1, part (d). The product was recrystallized from carbon tetrachloride and from isopropyl acetate to give 2-(p-acetylphenoxy)-2-methylpropionic acid as a pale cream solid, m.p. 108°-110°C.

후처리

  1. custom2-(p-Acetylphenoxy)-2-methylpropionic acid was prepared from 545 g
  2. customThe product was recrystallized from carbon tetrachloride and from isopropyl acetate

출처 및 근거

ORD 기록
ord-43972321ca904c3ca0b13546863795ca
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03948973

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