Hydrochloric Acid → 3-(Methylthio)-5-(trifluoromethyl)benzoic acid
반응식
[SH:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[C:5]([OH:7])=[O:6].[OH-].[Na+].[CH3:17]I.Cl>C(O)C>[CH3:17][S:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:12])([F:13])[F:14])[CH:10]=1)[C:5]([OH:7])=[O:6]참가 물질
6
실험 절차
To a solution of 10 g. (0.045 mole) of 3-mercapto-5-trifluoromethylbenzoic acid, and 100 ml. of 1N sodium hydroxide in 100 ml. of ethanol is added 3.8 ml. (0.06 mole) of methyl iodide. After the reaction has stirred at room temperature for one hour, it is acidified with 12N hydrochloric acid, and the precipitate of the final product is filtered and dried,8.6 g., m.p. 135°-140° C. A sample is sublimed at 175° C. and 0.03 mm pressure, m.p. 151°-152.5° C.
후처리
- filtrationthe precipitate of the final product is filtered
- customdried
- customis sublimed at 175° C.
출처 및 근거
- ORD 기록
- ord-6ccdc6fdae374e30a10ed670f7e67ae9
- 출처 데이터셋
- uspto-grants-1976_04
- 특허 번호
- US03953595
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