Water → HCID 18650307, 화합물

HRID 1613129노트

반응식

HRID 1613129 반응식
[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([OH:9])=O.[CH3:10][O:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][C:21]=1[O:22][CH3:23])[CH2:18][CH:17]([NH2:24])[CH2:16][CH2:15]2.CCOC1N(C(OCC)=O)C2C(=CC=CC=2)C=C1.O>CC#N.CCOCC.C(Cl)(Cl)Cl>[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([NH:24][CH:17]1[CH2:16][CH2:15][C:14]2[C:19](=[CH:20][C:21]([O:22][CH3:23])=[C:12]([O:11][CH3:10])[CH:13]=2)[CH2:18]1)=[O:9]

참가 물질

8

반응물 4

HCID 962WaterHCID 7405L-Pyroglutamic AcidHCID 278332-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinolineHCID 98162656,7-Dimethoxy-1,2,3,4-tetrahydronaphthalen-2-amine

생성물 1

HCID 18650307HCID 18650307, 화합물수율 81.6%

시약·촉매·용매 3

HCID 3283Diethyl Ether용매HCID 6212Chloroform용매HCID 6342Acetonitrile용매

실험 절차

To L-pyroglutamic acid (1 g, 7.7 mmoles) in CH3CN (80 mL), 1,2,3,4-tetrahydro-6,7-dimethoxy-2-naphtylamine (1.59 g, 7.7 mmoles) and EEDQ (2.85 g, 11 mmoles) were added under stirring. To the resulting mixture water was added till complete solubilization and the solution was kept at room temperature under stirring for 20 hours. The solvent was evapored and the residue taken up with CHCl3. Et2O was added under stirring. The solid which formed was filtered off giving 2 g of the title compound. Yield 81%.

후처리

  1. customwas kept at room temperature
  2. stirringunder stirring for 20 hours
  3. stirringunder stirring
  4. customThe solid which formed
  5. filtrationwas filtered off

출처 및 근거

ORD 기록
ord-b2ae8d7cfc954e9094b0d93259be5e91
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05192759

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