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Methyl iodide → HCID 58043345, 화합물

HRID 1617952
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HRID 1617952 반응식
[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([C:13]2[CH:14]=[CH:15][C:16](=O)[NH:17][CH:18]=2)=O)[CH:5]=[C:6]([Cl:8])[CH:7]=1.IC.[C:22](=[O:25])([O-])[O-].[K+].[K+].[CH3:28][S:29]([C:32]1[CH:37]=[CH:36][C:35](B(O)O)=[CH:34][CH:33]=1)(=[O:31])=[O:30].C(=O)([O-])O.[Na+].Cl.[NH2:47][OH:48]>O1CCOCC1.O.C1CC=CCCC=C1.C1CC=CCCC=C1.[Cl-].[Cl-].[Rh].[Rh]>[Cl:8][C:6]1[CH:5]=[C:4]([CH:9]([C:35]2[CH:36]=[CH:37][C:32]([S:29]([CH3:28])(=[O:31])=[O:30])=[CH:33][CH:34]=2)[CH2:10]/[C:11](/[C:13]2[CH:14]=[CH:15][C:22](=[O:25])[N:17]([CH3:16])[CH:18]=2)=[N:47]\[OH:48])[CH:3]=[C:2]([Cl:1])[CH:7]=1
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

10

반응물 6

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium Bicarbonate2회HCID 27343644-(Methanesulfonyl)phenylboronic acidHCID 66668301HCID 66668301, 화합물

생성물 1

HCID 58043345
HCID 58043345, 화합물

시약·촉매·용매 3

HCID 6436379Rhodium, di-mu-chlorobis((1,2,5,6-eta)-1,5-cyclooctadiene)di-촉매HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

In analogy to example 161, step 1, (E)-5-(3-(3,5-dichlorophenyl)acryloyl)pyridin-2(1H)-one was reacted with iodomethane in the presence of potassium carbonate. The product of this reaction was treated in analogy to example 203, step 1, with 4-(methylsulfonyl)phenylboronic acid in the presence of chloro(1,5-cyclooctadiene)rhodium(I) dimer and sodium hydrogen-carbonate in 1,4-dioxane and water at 60° C. The product of this reaction was reacted with hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate to give the title compound containing less than 10% of the corresponding Z isomer as an off-white solid, MS (ESI+): m/z=479.1 [M+H]+.

출처 및 근거

ORD 기록
ord-d0ab665af0c04f6e92646a09cc42bd7c
출처 데이터셋
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08765730B2

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