Hydrochloric Acid → Benzaldehyde

HRID 1632327

반응식

HRID 1632327 반응식
CCCNCC(O)CO[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=1[C:15]([CH2:17]CC1C=CC=CC=1)=[O:16].Cl.[OH:27]C(CNCCC)CO[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[C:37](=[O:46])CCC1C=CC=CC=1.[Na].ClCC1OC1.C(N)CC.Cl>>[OH:27][CH2:17][C:15]([C:14]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:16].[CH:37](=[O:46])[C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:31]=1

참가 물질

8

반응물 6

HCID 313Hydrochloric AcidHCID 4932PropafenoneHCID 7835EpichlorohydrinHCID 7852PropylamineHCID 367081-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one hydrochlorideHCID 5360545Sodium

생성물 2

HCID 240BenzaldehydeHCID 68490alpha-Hydroxyacetophenone

실험 절차

Propafenone (2'-(2-hydroxy-3-propylaminopropoxy)-3-phenylpropiophenone hydrochloride, German Pat. No. 2,001,431) is a substance having an anti-arrhythmic action. According to the said German patent, it is obtained by reacting 2-hydroxy-omega-phenylpropiophenone (as the sodium salt) with 1-chloro-2,3-epoxypropane and then reacting the resulting 2-(2',3'-epoxypropyl)-omega-phenylpropiophenone with n-propylamine and converting the product to the hydrochloride. This process gives a yield of only about 66%. Moreover, the starting material (2-hydroxy-omega-phenylpropiophenone) required for the reaction can only be obtained with difficulty from 2-hydroxyacetophenone by condensing with benzaldehyde and then hydrogenating the reaction product.

후처리

  1. customit is obtained
  2. customThis process gives a yield of only about 66%

출처 및 근거

ORD 기록
ord-d18897477b8b4ce88d75b88e42e7326c
출처 데이터셋
uspto-grants-1984_10
특허 번호
US04474986

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