P-Toluic Acid → HCID 178473962, 화합물

HRID 1637956

반응식

HRID 1637956 반응식
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:16])(=[O:3])[CH3:2].[CH3:17][C:18]1[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][CH:19]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C1C=CC2N(O)N=NC=2C=1.CCN(C(C)C)C(C)C>CN(C=O)C>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=2)[C:6](=[C:22]([OH:23])[C:21]2[CH:25]=[CH:26][C:18]([CH3:17])=[CH:19][CH:20]=2)[C:5]1=[O:16])(=[O:3])[CH3:2]

참가 물질

7

반응물 5

HCID 7470P-Toluic AcidHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 28393291-Acetyl-5-nitroindolin-2-one

생성물 1

HCID 178473962HCID 178473962, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Prepared analogously to Example 10(a) from 1-acetyl-5-nitro-2-indolinone and 4-methyl-benzoic acid in dry DMF in the presence of TBTU, HOBT and Hunig's base (20° C., overnight) and final purification by column chromatography on silica gel with CH2Cl2 as eluant.

후처리

  1. customfinal purification by column chromatography on silica gel with CH2Cl2 as eluant

출처 및 근거

ORD 기록
ord-cfac0bb4acbb4dc58561b1a882d56e8f
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06043254

연결된 노트

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