Hydrochloric Acid → 3,5-Diamino-8-chloro-2,3-dihydro-quinoline-4-one

HRID 1683492노트

반응식

HRID 1683492 반응식
Cl.C([N:5]1[C:14]2[C:9](=[C:10]([NH:16]C(=O)C)[CH:11]=[CH:12][C:13]=2[Cl:15])[C:8](=[O:20])[CH:7]([NH:21]C(=O)C)[CH2:6]1)(=O)C.[OH-].[Na+]>C(Cl)(Cl)Cl>[NH2:21][CH:7]1[C:8](=[O:20])[C:9]2[C:14](=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[NH2:16])[NH:5][CH2:6]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 224495101-Acetyl-3,5-diacetylamino-8-chloro-2,3-dihydro-quinoline-4-one

생성물 1

HCID 224495153,5-Diamino-8-chloro-2,3-dihydro-quinoline-4-one

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
110 °C

실험 절차

8 ml of 6N hydrochloric acid was added to 514 mg of the compound prepared in (2) above, and the mixture was heated at 110° C. for 1.5 hours while stirring. After cooling chloroform was added to it, followed by the addition of 50 ml of 1N aqueous solution of sodium hydroxide while stirring. The chloroform layer was extracted, the extract was washed with saturated brine and dried over anhydrous sodium sulfate. The product was concentrated to produce 260 mg of the title compound.

후처리

  1. additionwas added to it
  2. stirringwhile stirring
  3. extractionThe chloroform layer was extracted
  4. washthe extract was washed with saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationThe product was concentrated

출처 및 근거

ORD 기록
ord-fe4b9b068e13462192558088df62be4e
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05637770

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