Iodoacetamide → 2-((3-Nitrobenzoyl)imino)-5-nitro-3(2H)-thiazoleacetamide

HRID 1701837

반응식

HRID 1701837 반응식
[H-].[Na+].[N+:3]([C:6]1[CH:7]=[C:8]([CH:20]=[CH:21][CH:22]=1)[C:9]([NH:11][C:12]1[S:13][C:14]([N+:17]([O-:19])=[O:18])=[CH:15][N:16]=1)=[O:10])([O-:5])=[O:4].I[CH2:24][C:25]([NH2:27])=[O:26]>CN(C)C=O>[N+:3]([C:6]1[CH:7]=[C:8]([CH:20]=[CH:21][CH:22]=1)[C:9]([N:11]=[C:12]1[N:16]([CH2:24][C:25]([NH2:27])=[O:26])[CH:15]=[C:14]([N+:17]([O-:19])=[O:18])[S:13]1)=[O:10])([O-:5])=[O:4]

참가 물질

5

반응물 3

HCID 3727IodoacetamideHCID 24758Sodium hydrideHCID 2989303-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide

생성물 1

HCID 30618272-((3-Nitrobenzoyl)imino)-5-nitro-3(2H)-thiazoleacetamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

By following the procedure of Example 5, but using a dispersion of sodium hydride (2.1 g 60% w/w) in mineral oil, 3-nitro-N-(5-nitro-2-thiazolyl)benzamide (11.8 g), N,N-dimethylformamide (100 ml) and 2-iodoacetamide (11.1 g), there was obtained 2-[(3-nitrobenzoyl)imino]-5-nitro-4-thiazoline-3-acetamide, m.pt 251°-252°, after recrystallization from pyridine.

출처 및 근거

ORD 기록
ord-2349b54282b249599bf09d1921f4e09b
출처 데이터셋
uspto-grants-1983_04
특허 번호
US04379156

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