Hydrochloric Acid → HCID 22759262, 화합물

HRID 1704342노트

반응식

HRID 1704342 반응식
[BH4-].[Na+].[C:3]([CH:6]([CH2:16][CH2:17][CH2:18][CH:19]([OH:29])[CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])(=[O:5])[CH3:4].[OH-].[Na+].Cl>CCOCC.O>[OH:5][CH:3]([CH:6]([CH2:16][CH2:17][CH2:18][CH:19]([OH:29])[CH2:20][O:21][C:22]1[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH3:4]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 4311764Sodium borohydrideHCID 22759241HCID 22759241, 화합물

생성물 1

HCID 22759262HCID 22759262, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

Sodium borohydride (1.2 g., 0.03 mole) is added to a solution of 8-acetyl-12-hydroxy-13-(4-fluorophenoxy)tridecanoic acid (15.4 g., 0.04 mole) and sodium hydroxide (2.0 g., 0.05 mole) in 70 ml. of water. The resulting solution is allowed to stand at room temperature for 19 hours, and is then acidified to Congo Red with concentrated hydrochloric acid. The oily product is taken up in ether, washed with water and dried over sodium sulfate. The ether is evaporated leaving 12.8 g. of the crude title compound as a brown oil.

후처리

  1. washwashed with water
  2. dry with materialdried over sodium sulfate
  3. customThe ether is evaporated
  4. customleaving 12.8 g

출처 및 근거

ORD 기록
ord-9e967ea8d1ce4fe083a54cef84d58277
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04126629

반응 노트

불러오는 중…