[BH4-].[Na+].[NH2:3][C:4]1[C:9]([Cl:10])=[CH:8][CH:7]=[C:6]([Cl:11])[C:5]=1[C:12](=O)[CH3:13].[C:15]([S-:17])#[N:16].[K+].Cl>C(O)C.O>[Cl:11][C:6]1[CH:7]=[CH:8][C:9]([Cl:10])=[C:4]2[C:5]=1[CH:12]([CH3:13])[NH:16][C:15](=[S:17])[NH:3]2
At a temperature of 65° C., sodium borohydride (0.13 g, 3.4 mmol) was added to a solution of 1-(2-amino-3,6-dichloro-phenyl)-ethanone (1.16 g, 5.7 mmol) in ethanol (12 ml), and the mixture was heated overnight (65° C.). Water (14.4 ml), KSCN (0.61 g, 6.3 mmol) and concentrated aqueous hydrogen chloride solution (3.6 ml) were then added subsequently, and the mixture was again heated (3 h, 65° C.). The majority of the title compound precipitated upon cooling and could be isolated in pure form by filtration and washing with water and ethanol to yield a light yellow solid (0.96 g, 69%).
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