Methyl iodide → HCID 59463819, 화합물
반응식
[Br:1][C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5](=[O:12])[NH:4][CH:3]=1.[CH3:13]I>C(Cl)(Cl)Cl.C(=O)([O-])[O-].[Ag+].[Ag+]>[Br:1][C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]([O:12][CH3:13])=[N:4][CH:3]=1참가 물질
5
반응 조건
- 온도
- 50 °C
실험 절차
47.7 g (209 mmol) of 4-bromo-5,6,7,8-tetrahydro-2H-isoquinolin-1-one are dissolved in 1 l of chloroform and, after addition of 77.8 g (282 mmol) of silver(I) carbonate and 53.5 ml (118.7 g, 836 mmol) of methyl iodide, stirred at 50° C. for 3 h. After cooling, the suspension is filtered through Celite, concentrated and chromatographed on silica gel using n-heptane with addition of 2% ethyl acetate. A colorless oil (42.5 g, 84% yield) is obtained.
후처리
- temperatureAfter cooling
- filtrationthe suspension is filtered through Celite
- concentrationconcentrated
- customchromatographed on silica gel
- additionwith addition of 2% ethyl acetate
출처 및 근거
- ORD 기록
- ord-7fb22eb221004955a6bad02614f70010
- 출처 데이터셋
- uspto-grants-2010_09
- 특허 번호
- US07795278B2
반응 노트
불러오는 중…