Hydrogen Bromide → 4-Chloroquinolin-6-ol

HRID 1720276

반응식

HRID 1720276 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12]C)[CH:10]=2)[N:5]=[CH:4][CH:3]=1.Br.[OH-].[Na+]>O>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[N:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 14798Sodium HydroxideHCID 2283484-Chloro-6-methoxyquinoline

생성물 1

HCID 184331324-Chloroquinolin-6-ol수율 56.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 4.99 g (18.1 mmol) of 4-chloro-6-methoxyquinoline and 50 mL of 48% hydrobromic acid is heated under reflux for seven hours. Upon cooling to room temperature, the reaction solution afforded a dark solid that was then slurried in water. The aqueous mixture was adjusted to pH 10 by the addition of 4N sodium hydroxide. The resulting solid was filtered, washed with water and air-dried to give 1.83 g (56%) of 4-chloroquinolin-6-ol: m.p. 223° C.

후처리

  1. temperatureunder reflux for seven hours
  2. customthe reaction solution afforded a dark solid
  3. filtrationThe resulting solid was filtered
  4. washwashed with water
  5. customair-dried

출처 및 근거

ORD 기록
ord-c0fdfe9b5da74a6c90547c030d1edfe9
출처 데이터셋
uspto-grants-1996_04
특허 번호
US05506235

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