Hydrochloric Acid → 2'-Fluorobiphenyl-3-carboxylic acid

HRID 1731803노트

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HRID 1731803 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[C:10]([CH3:14])[CH:11]=[CH:12][CH:13]=1.[Mn]([O-])(=O)(=O)=[O:16].[K+].S(=O)(O)[O-].[Na+].Cl.[OH2:27]>C(O)(C)(C)C.[O-2].[O-2].[Mn+4]>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=1)[C:14]([OH:16])=[O:27]

참가 물질

8

반응물 5

HCID 313Hydrochloric AcidHCID 962WaterHCID 516875Potassium Permanganate2회HCID 128530412-Fluoro-3'-methyl-1,1'-biphenylHCID 23665763Sodium Bisulfite

생성물 1

HCID 27826832'-Fluorobiphenyl-3-carboxylic acid

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6386tert-Butanol용매

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온도
90 °C

실험 절차

A mixture of 7.0 g 3-(2-fluorophenyl)-toluene and 29.5 g potassium permanganate in 500 ml t-butanol and 100 ml water was heated at 90° C. for 18 hours. The reaction mixture was cooled to room temperature, sufficient sodium bisulfite was added to dissolve the remaining potassium permanganate and manganese dioxide, and the pH was adjusted to 1 with hydrochloric acid. The resulting precipitate was collected by filtration, redissolved in ethyl acetate and this solution was dried and evaporated yielding the product as a white solid of m.p. 147°-148° C. after recrystallization from hexanes (5.7 g, 70% yield). NMR (DMSO-d6, 250 MHz): 8.2-7.3 (m, 8H).

후처리

  1. temperatureThe reaction mixture was cooled to room temperature
  2. filtrationThe resulting precipitate was collected by filtration
  3. dissolutionredissolved in ethyl acetate
  4. customthis solution was dried
  5. customevaporated

출처 및 근거

ORD 기록
ord-56c6ddec21f640c8814e715ec24ceacc
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04623650

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