Water → 2-Benzyl-2-methyl-3-butenitrile

HRID 1732144

반응식

HRID 1732144 반응식
O.[CH2:2](Cl)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:10][C:11](=[CH:14][CH3:15])[C:12]#[N:13].[OH-].[Na+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C1(C)C=CC=CC=1>[CH3:10][C:11]([CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)([CH:14]=[CH2:15])[C:12]#[N:13]

참가 물질

7

반응물 4

HCID 962WaterHCID 7503Benzyl ChlorideHCID 14798Sodium HydroxideHCID 299352-Methyl-2-butenenitrile

생성물 1

HCID 54638042-Benzyl-2-methyl-3-butenitrile

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 1140Toluene용매

실험 절차

Into a 500 ml 4-neck flask, equipped with a stirrer, reflux cooler, dropping funnel and water separator, 126.5 g (1 mole) of benzylchloride, 81 g (1 mole) of 2-methyl-2-butene-nitrile, 100 ml of toluene, and 10 g of tetrabutylammonium bromide were first introduced and heated to reflux. To this mixture, 40 g (1 mole) of solid sodium hyroxide were added in portions. The reaction mixture was then maintained one more hour at reflux. Thereupon, it was washed to neutrality with water, the phases were separated and the organic phase distilled as described in Example 1. The yield in desired product was 103.5 g, corresponding to 61% of the theoretical.

후처리

  1. customInto a 500 ml 4-neck flask, equipped with a stirrer
  2. temperaturereflux cooler
  3. temperatureheated to reflux
  4. temperatureThe reaction mixture was then maintained one more hour
  5. temperatureat reflux
  6. washThereupon, it was washed
  7. customthe phases were separated
  8. distillationthe organic phase distilled

출처 및 근거

ORD 기록
ord-e90031ab58bd475f9e2ba9098024d0ba
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04625046

연결된 노트

불러오는 중…