Hydrochloric Acid → HCID 118162198, 화합물

HRID 1749534

반응식

HRID 1749534 반응식
[ClH:1].[F:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH2:12][CH2:13][NH2:14])=[CH:8][NH:9]2)=[CH:5][CH:4]=1.Cl.CS(C)=[O:18]>>[ClH:1].[NH2:14][CH2:13][CH2:12][CH:7]1[C:6]2[C:10](=[CH:11][C:3]([F:2])=[CH:4][CH:5]=2)[NH:9][C:8]1=[O:18]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 679Dimethyl SulfoxideHCID 30850786-Fluoro-1H-indole-3-ethylamine monohydrochloride

생성물 1

HCID 118162198HCID 118162198, 화합물수율 47%

반응 조건

온도
50 °C

실험 절차

To a solution of 2-(6-fluoro-1H-indol-3-yl)ethanamine hydrochloride (500 mg, 2.3 mmol) in DMSO (0.8 mL) was added hydrochloric acid (36%, 1.3 g, 12.8 mmol). The resulting reaction mixture was stirred at 50° C. in a sealed tube for 6 h. After cooling to room temperature, the reaction mixture was filtered. The resulting cake was stirred in EtOH (5 mL). The mixture was filtered and dried to give the desired product (250 mg, 1.28 mmol, 47% yield) as a yellow solid. MS (ESI) m/z 195.1 [M+H]+.

후처리

  1. customThe resulting reaction mixture
  2. temperatureAfter cooling to room temperature
  3. filtrationthe reaction mixture was filtered
  4. stirringThe resulting cake was stirred in EtOH (5 mL)
  5. filtrationThe mixture was filtered
  6. customdried

출처 및 근거

ORD 기록
ord-02d7faa9def14b0a8852b78dc2eb5fce
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156798B2

연결된 노트

불러오는 중…