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Hydrochloric Acid → Ethyl 4-(3-chlorophenyl)-1,2-dihydro-2-oxo-6-[(4-phenyl-2-thiazolyl)carbonyl]-3-quinolinecarboxylate

HRID 1830806
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반응식

HRID 1830806 반응식
[CH2:1]([O:3][C:4](=[O:37])[CH2:5][C:6](=[O:36])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([C:16]2[S:17][CH:18]=[C:19]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:20]=2)=[O:15])=[CH:10][C:9]=1[C:27](=O)[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[CH:29]=1)[CH3:2].CC(O)(C)C.[K].Cl>COCCOC>[Cl:34][C:30]1[CH:29]=[C:28]([C:27]2[C:9]3[C:8](=[CH:13][CH:12]=[C:11]([C:14]([C:16]4[S:17][CH:18]=[C:19]([C:21]5[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=5)[N:20]=4)=[O:15])[CH:10]=3)[NH:7][C:6](=[O:36])[C:5]=2[C:4]([O:3][CH2:1][CH3:2])=[O:37])[CH:33]=[CH:32][CH:31]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6386tert-ButanolHCID 5462222PotassiumHCID 22048474N-[2-(3-chlorobenzoyl)-4-[(4-phenyl-2-thiazolyl)carbonyl]phenyl]-3-oxo-beta-alanine ethyl ester

생성물 1

HCID 22048464Ethyl 4-(3-chlorophenyl)-1,2-dihydro-2-oxo-6-[(4-phenyl-2-thiazolyl)carbonyl]-3-quinolinecarboxylate수율 70%

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

A mixture of intermediate (17) (0.048 mol) in DME (250 ml) was cooled on an ice bath and 2-methyl-2-propanol, potassium salt (0.096 mol) was added portionwise. The mixture was stirred at a low temperature for 15 min, poured out into ice water and acidified with HCl 3N. The precipitate was filtered off, washed with water, pasted up with CH3CN and diethyl ether, then dried, yielding 17.3 g (70%) of ethyl 4-(3-chlorophenyl)-1,2-dihydro-2-oxo-6-[(4-phenyl-2-thiazolyl)carbonyl]-3-quinolinecarboxylate (intermediate 18), mp 261° C.

후처리

  1. temperaturewas cooled on an ice bath
  2. filtrationThe precipitate was filtered off
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-2d1c8edcb2c944b5a75a2d2e8d204d48
출처 데이터셋
uspto-grants-2006_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07067531B2

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