Lithium hydroxide, monohydrate → 3-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic Acid

HRID 1831787

반응식

HRID 1831787 반응식
C[O:2][C:3](=[O:24])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([NH:12][C:13](=[O:23])[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[Cl:22])[CH:5]=1.O.[OH-].[Li+]>CO.O.Cl>[Cl:22][C:16]1[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=1[CH2:14][C:13]([NH:12][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[O:10][CH3:11])[C:3]([OH:24])=[O:2])=[O:23]

참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 696522653-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic acid methyl ester

생성물 1

HCID 220524883-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic Acid

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 22242641Methanol--water (1/1)용매

실험 절차

To a solution of 400 mg 3-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic acid methyl ester in 5 ml MeOH/H2O 2:1 56 mg lithium hydroxide monohydrate were added and the mixture was stirred over night. The suspension was diluted with 5 ml concentrated HCl to precipitate the acid. After filtration the filter cake was washed twice with water and then dried to yield the acid as a white powder.

후처리

  1. customto precipitate the acid
  2. filtrationAfter filtration the filter cake
  3. washwas washed twice with water
  4. customdried

출처 및 근거

ORD 기록
ord-69c7a0c252af43e5b0a9aa16263b32a2
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067665B2

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