Formamide → N-(1-pyridin-4-ylethyl)formamide

HRID 1831806노트

반응식

HRID 1831806 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7](=O)[CH3:8])=[CH:3][CH:2]=1.[CH:10]([NH2:12])=[O:11].[OH-].[Na+]>C(O)=O.O>[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([NH:12][CH:10]=[O:11])[CH3:8])=[CH:3][CH:2]=1

참가 물질

6

반응물 3

HCID 713FormamideHCID 142824-AcetylpyridineHCID 14798Sodium Hydroxide

생성물 1

HCID 2771720N-(1-pyridin-4-ylethyl)formamide

시약·촉매·용매 2

HCID 284Formic Acid용매2회HCID 962Water용매

실험 절차

1-Pyridin-4-yl-ethanone (24.2 g, 199.77 mmol) and 10 ml of formic acid were heated to 180° C. and formamide (126 g, 2.797 mol) in 10 ml of formic acid was added within 30 min. The mixture was stirred for 90 min., cooled and poured in 100 ml of water. After addition of conc. sodium hydroxide solution until pH13 the product was extracted with diethyl-ether. The organic layer was dried with MgSO4 and evaporated. Purification by distillation (165° C./4 mbar) yields pure product.

후처리

  1. temperaturecooled
  2. extractionwas extracted with diethyl-ether
  3. dry with materialThe organic layer was dried with MgSO4
  4. customevaporated
  5. customPurification
  6. distillationby distillation (165° C./4 mbar)
  7. customyields pure product

출처 및 근거

ORD 기록
ord-51a7bbae96154048b61fe7ecbbdc2a52
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07067665B2

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