Acetic Acid → (1,1'-Biphenyl)-4-butanoic acid, gamma-hydroxy-

HRID 1856512

반응식

HRID 1856512 반응식
[C:1]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:6]=[CH:5][C:4]([C:7]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[O:8])=[CH:3][CH:2]=1.[OH-].[Na+].[BH4-].[Na+].C(O)(=O)C>O>[OH:8][CH:7]([C:4]1[CH:5]=[CH:6][C:1]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:2][CH:3]=1)[CH2:9][CH2:10][C:11]([OH:13])=[O:12]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 3335FenbufenHCID 14798Sodium HydroxideHCID 4311764Sodium borohydride

생성물 1

HCID 16072199(1,1'-Biphenyl)-4-butanoic acid, gamma-hydroxy-

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A 25.4 g. portion of 3-(4-biphenylylcarbonyl)propionic acid is dissolved in 2 liters of water made alkaline with sodium hydroxide. A 37.8 g. portion of sodium borohydride is added and the mixture is stirred for 2 hours. The suspension is then slowly poured into 100 ml. of glacial acetic acid. The mixture is cooled and the resulting solid is filtered, washed with water and dried giving the desired product, m.p. 139°-140° C.

후처리

  1. additionThe suspension is then slowly poured into 100 ml
  2. temperatureThe mixture is cooled
  3. filtrationthe resulting solid is filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-683b6ab37ab6474ab8171af01f918ae9
출처 데이터셋
uspto-grants-1980_08
특허 번호
US04219668

연결된 노트

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