Hydrochloric Acid → Luteolin

HRID 1862502

반응식

HRID 1862502 반응식
[CH:1]1[C:6]([C:7]2[O:17][C:16]3[CH:15]=[C:14]([OH:18])[CH:13]=[C:12]([OH:19])[C:11]=3[C:9](=[O:10])[C:8]=2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=[CH:5][C:4]([OH:32])=[C:3]([OH:33])[CH:2]=1.[OH-].[Na+].[Na].Cl>O>[CH:1]1[C:6]([C:7]2[O:17][C:16]3[CH:15]=[C:14]([OH:18])[CH:13]=[C:12]([OH:19])[C:11]=3[C:9](=[O:10])[CH:8]=2)=[CH:5][C:4]([OH:32])=[C:3]([OH:33])[CH:2]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 5280804IsoquercetinHCID 5360545Sodium

생성물 1

HCID 5280445Luteolin수율 95%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
5 °C

실험 절차

3.5 g of isoquercetin are carefully suspended in 500 ml of demineralized water at 60° C., and 8.8 ml of 32% strength aqueous sodium hydroxide solution are introduced into the resulting yellow suspension. During this addition, a dark-red colored clear solution forms. 25 g of sodium d-thionite are added at 60° C. and the mixture is stirred for 12 h at this temperature. The mixture is then cooled to 5° C. and carefully neutralized with 37% strength hydrochloric acid, the solution immediately turning cloudy. The mixture is stirred for 1 h at 0° C. Customary work-up gives 2.05 g of luteolin with a purity of 98.8%.

후처리

  1. additionDuring this addition
  2. stirringThe mixture is stirred for 1 h at 0° C

출처 및 근거

ORD 기록
ord-2454d02528e943899e1b87e7e627bb8d
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06538021B1

연결된 노트

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