O-Cresol → Benzene, 1-methyl-2-(1-methylethoxy)-

HRID 1862797노트

반응식

HRID 1862797 반응식
[C:1]1([CH3:8])[C:6]([OH:7])=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].[CH:11](Br)([CH3:13])[CH3:12]>CS(C)=O>[C:1]1([CH3:8])[CH:2]=[CH:3][CH:4]=[CH:5][C:6]=1[O:7][CH:11]([CH3:13])[CH3:12]

참가 물질

5

반응물 3

HCID 335O-CresolHCID 63582-BromopropaneHCID 14798Sodium Hydroxide

생성물 1

HCID 141785Benzene, 1-methyl-2-(1-methylethoxy)-수율 71.8%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매2회

실험 절차

To a solution of 54.1 g (0.5 mole) of ortho-cresol in 150 ml of DMSO was added portionwise and with stirring 12 g of 57% sodium hydroxide. This addition was exothermic to 45° C. After 2 hours at ambient temperature, 61.5 g (0.5 mole) of isopropyl bromide in 50 ml of DMSO was added dropwise with stirring. After another 2 hours, the reaction mixture was poured into 1000 ml of ice water and extracted with ether. Distillation of the dried extract gave 53.9 g of product as a colorless liquid; b.p. 94°-96° C. (30 mm).

후처리

  1. additionThis addition
  2. customwas exothermic to 45° C
  3. waitAfter another 2 hours
  4. extractionextracted with ether
  5. distillationDistillation of the dried
  6. extractionextract

출처 및 근거

ORD 기록
ord-1470bb5dd1f045a89c50aed3f17f9ca7
출처 데이터셋
uspto-grants-1979_09
특허 번호
US04166735

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