Hydrochloric Acid → HCID 2778529, 화합물

반응식

ClC1C=CC=CC=1C([O:6][C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)=O.[Cl-].[Al+3].[Cl-].[Cl-].Cl.[CH:23]([Cl:26])(Cl)Cl>>[Cl:26][C:23]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:7]([C:12]1[CH:11]=[C:10]([F:13])[CH:9]=[CH:8][C:7]=1[OH:6])=[O:6]

참가 물질

반응물 4

HCID 313Hydrochloric Acid

HCID 6212Chloroform

HCID 27982194-Fluorophenyl 2-chlorobenzoate

HCID 6451240Aluminum(III) Chloride

생성물 1

HCID 2778529HCID 2778529, 화합물수율 56.3%

실험 절차

To a stirred solution of 2.5 g of compound A was added in small portions 1.47 g of powdered aluminum chloride at 130° C. and stirring was continued for another 1 hour. After cooling 1N HCl and chloroform was added to the reaction mixture and the organic layer was separated. The aqueous layer was extracted with chloroform. The combined organic layer was dried over magnesium sulfate and distilled to remove the solvent. The crude product thus obtained was crystallized from hexane to obtain 1.41 g of compound B. Yield: 56.3%.

후처리

additionwas added to the reaction mixture
customthe organic layer was separated
extractionThe aqueous layer was extracted with chloroform
dry with materialThe combined organic layer was dried over magnesium sulfate
distillationdistilled
customto remove the solvent
customThe crude product thus obtained
customwas crystallized from hexane

출처 및 근거

ORD 기록: ord-91e0aecb40ce44f493b3ae70ab072de4
출처 데이터셋: uspto-grants-2000_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: USRE036832

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