반응식
Cl.[OH:2][C:3]1[N:8]=[CH:7][CH:6]=[CH:5][N:4]=1.Cl[CH2:10][C:11]([OH:13])=[O:12].[OH-].[Na+].Cl>>[O:2]=[C:3]1[N:8]=[CH:7][CH:6]=[CH:5][N:4]1[CH2:10][C:11]([OH:13])=[O:12]참가 물질
5
반응 조건
- 온도
- 105 °C
실험 절차
To a mixture of 2-hydroxypyrimidine hydrochloride (1.00 g, 7.54 mmol) and chloroacetic acid (0.713 g, 7.54 mmol) was added 5 N sodium hydroxide solution (4.5 ml). The reaction mixture was heated at 105° C. for 2 h. After cooling to ambient temperature, the reaction was neutralized with 2 N hydrochloric acid (3.8 ml). The title compound was collected by crystallization and filtration as a pale yellow solid. 1H NMR (DMSO-d6) δ: 13.2 (s, 1H), 8.59 (dd, J=3.9, 3.0 Hz, 1H), 8.16 (dd, J=6.4, 2.8 Hz, 1H), 6.46 (dd, J=6.4, 4.1 Hz, 1H), 4.58 (s, 2H). LC/MS 155.2 (M+1)+.
후처리
- temperatureAfter cooling to ambient temperature
- filtrationThe title compound was collected by crystallization and filtration as a pale yellow solid
출처 및 근거
- ORD 기록
- ord-ee4866560b6249ca93a2fefb921f3271
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08501786B2
연결된 노트
불러오는 중…