Phthalic Anhydride → 2-(5-Methylpyridin-2-yl)isoindoline-1,3-dione
반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.[C:9]1(=O)[O:14][C:12](=[O:13])[C:11]2=[CH:15][CH:16]=[CH:17][CH:18]=[C:10]12.CCN(C(C)C)C(C)C>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12](=[O:13])[C:11]3[C:10](=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:9]2=[O:14])=[N:6][CH:7]=1참가 물질
5
실험 절차
A mixture containing 5-methylpyridin-2-amine (5.4 g, 50 mmol), phthalic anhydride (8.88 g, 60 mmol) and DIEA (19 ml, 110 mmol) in toluene (30 ml) is refluxed for 18 hours, and cooled. The solvent is removed by rotary evaporation. The crude product is purified by silica gel flash chromatography to afford 2-(5-methylpyridin-2-yl)isoindoline-1,3-dione as a dark brown oil. LC-MS m/z: 239.1 (M+1).
후처리
- temperatureis refluxed for 18 hours
- temperaturecooled
- customThe solvent is removed by rotary evaporation
- customThe crude product is purified by silica gel flash chromatography
출처 및 근거
- ORD 기록
- ord-aaa858a97e9949e89a945be030ed087e
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08507491B2
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