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Hydrochloric Acid → 3-Ethyl-1-(p-tolyl)-3-azabicyclo[3.1.0]hexane hydrochloride

HRID 1903275
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인쇄 미리보기

반응식

HRID 1903275 반응식
[C:1]1([CH3:13])[CH:6]=[CH:5][C:4]([C:7]23[CH2:12][CH:11]2[CH2:10][NH:9][CH2:8]3)=[CH:3][CH:2]=1.[CH2:14](I)[CH3:15].C(=O)([O-])[O-].[Na+].[Na+].[ClH:23]>CCOCC.C1(C)C=CC=CC=1>[ClH:23].[CH2:14]([N:9]1[CH2:10][CH:11]2[C:7]([C:4]3[CH:3]=[CH:2][C:1]([CH3:13])=[CH:6][CH:5]=3)([CH2:12]2)[CH2:8]1)[CH3:15]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 6340IodoethaneHCID 10340Sodium CarbonateHCID 47953Bicifadine

생성물 1

HCID 160477373-Ethyl-1-(p-tolyl)-3-azabicyclo[3.1.0]hexane hydrochloride

시약·촉매·용매 2

HCID 1140Toluene용매
HCID 3283
Diethyl Ether
용매

실험 절차

A mixture of 7.4 g. of 1-(p-tolyl)-3-azabicyclo[3.1.0]hexane (Example 32), 7.3 g. of ethyl iodide and 8.9 g. of sodium carbonate in 60 ml. of toluene is heated at reflux for 18 hrs. Filtration and evaporation of this mixture gives a residue which is dissolved in ether. Addition of ethanolic hydrogen chloride gives a precipitate which is recrystallized from acetonitrile to give the desired product as colorless crystals, m.p. 175°-176° C.

후처리

  1. additionA mixture of 7.4 g
  2. temperatureat reflux for 18 hrs
  3. filtrationFiltration and evaporation of this mixture
  4. customgives a residue which
  5. customgives a precipitate which
  6. customis recrystallized from acetonitrile

출처 및 근거

ORD 기록
ord-8536fa9b8caa4af6b5beeb3361183309
출처 데이터셋
uspto-grants-1984_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04435419

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