Hydrochloric Acid → 1-(2-Chloro-6-fluorophenyl)ethan-1-ol

HRID 1903834노트

반응식

HRID 1903834 반응식
[CH3:1][C:2]([C:4]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:5]=1[F:11])=[O:3].[BH4-].[Na+].[OH-].[Na+].Cl>C(O)(C)C.O>[Cl:10][C:9]1[CH:8]=[CH:7][CH:6]=[C:5]([F:11])[C:4]=1[CH:2]([OH:3])[CH3:1]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 27735781-(2-Chloro-6-fluorophenyl)ethan-1-one2회HCID 4311764Sodium borohydride

생성물 1

HCID 133042791-(2-Chloro-6-fluorophenyl)ethan-1-ol

시약·촉매·용매 2

HCID 962Water용매HCID 3776Isopropanol용매

실험 절차

2-chloro-6-fluoroacetophenone of (A) (45.0 g, 0.26 mol) is dissolved in isopropyl alcohol (98 ml) and NaBH4 (4.9 g, 0.13 mol) is added. The resultant mixture is warmed to 55° C. for about 16 hours. A solution of NaOH 10.4 g, 0.26 mol) in water (41. ml) is then added. After 1 hour at 55° C., this reaction mixture is cooled and acidified with diluted HCl. Extraction with chloroform provided pure title product (45.1 g, 99.1%).

후처리

  1. temperaturethis reaction mixture is cooled
  2. extractionExtraction with chloroform provided pure title product (45.1 g, 99.1%)

출처 및 근거

ORD 기록
ord-1b8f09cf9d514dc2a73735722d863125
출처 데이터셋
uspto-grants-1984_03
특허 번호
US04438271

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