Hydrochloric Acid → 4-[4-(Benzenesulfonylamino)-phenyl]-butyric acid

HRID 1919232

반응식

HRID 1919232 반응식
C[O:2][C:3](=[O:14])[CH2:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=1.CCN(CC)CC.[C:22]1([S:28](Cl)(=[O:30])=[O:29])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[NH4+].[Cl-].[Li+].[OH-].Cl>C(Cl)Cl>[C:22]1([S:28]([NH:13][C:10]2[CH:11]=[CH:12][C:7]([CH2:6][CH2:5][CH2:4][C:3]([OH:2])=[O:14])=[CH:8][CH:9]=2)(=[O:30])=[O:29])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

참가 물질

8

반응물 6

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 7369Benzenesulfonyl chlorideHCID 8471TriethylamineHCID 25517Ammonium ChlorideHCID 88628Methyl 4-aminobenzenebutanoate

생성물 1

HCID 98400354-[4-(Benzenesulfonylamino)-phenyl]-butyric acid수율 96.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 40 (500 mg, 2.59 mmol) in CH2Cl2 at room temperature were added Et3N (901 μL, 6.48 mmol) followed by benzenesulfonyl chloride (661 μL, 5.18 mmol). The mixture was stirred overnight at room temperature then treated with a saturated aqueous solution of NH4Cl. The phases were separated and the organic layer was extracted several times with CH2Cl2. The combined organic extracts were dried over (MgSO4) then evaporated under reduced pressure. The residue was dissolved in a solvent mixture of THF (25 mL) and water (25 mL) then LiOH (1.08 g, 25.9 mmol) was added. The mixture was heated at 50° C. for 1 h then treated with HCl (1N) until pH2. The phases were separated and the aqueous layer was extracted several times with AcOEt. The combined organic extracts were dried over (MgSO4) then evaporated. The crude was purified by flash chromatography using CH2Cl2/MeOH (95:5) as solvent mixture yielding 41 (800 mg, 96%) as a white solid

후처리

  1. customThe phases were separated
  2. extractionthe organic layer was extracted several times with CH2Cl2
  3. dry with materialThe combined organic extracts were dried over (MgSO4)
  4. customthen evaporated under reduced pressure
  5. dissolutionThe residue was dissolved in a solvent mixture of THF (25 mL) and water (25 mL)
  6. temperatureThe mixture was heated at 50° C. for 1 h
  7. customThe phases were separated
  8. extractionthe aqueous layer was extracted several times with AcOEt
  9. dry with materialThe combined organic extracts were dried over (MgSO4)
  10. customthen evaporated
  11. customThe crude was purified by flash chromatography

출처 및 근거

ORD 기록
ord-d067cecd5a264c5a93ff09b10a778ee4
출처 데이터셋
uspto-grants-2012_05
특허 번호
USRE043343E1

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