Ethanol → 3-Aminoquinoline

HRID 1938334

반응식

HRID 1938334 반응식
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[CH:9][CH:8]=2)([O-])=O.C(O)C.C(OCC)(=O)C.[Sn](Cl)Cl>[Pt]=O.[Pd].[Fe].[Zn].C(O)(=O)C.C1COCC1.CO>[NH2:1][C:4]1[CH:5]=[N:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[CH:9][CH:8]=2

참가 물질

12

반응물 4

HCID 702EthanolHCID 8857Ethyl AcetateHCID 24479Stannous ChlorideHCID 255513-Nitroquinoline

생성물 1

HCID 113753-Aminoquinoline

시약·촉매·용매 7

HCID 23925Iron촉매HCID 23938Palladium촉매HCID 23994Zinc촉매HCID 82844Platinum oxide (PtO)촉매HCID 176Acetic Acid용매HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

The 3-nitroquinoline derivative of the formula (c) is then catalytically reduced in an inert solvent such as ethanol, ethyl acetate, methanol or THF, using platinum oxide or palladium/carbon, or reduced by iron or zinc and acetic acid or tin (II) chloride, to give the 3-aminoquinoline derivative of the formula (d).

출처 및 근거

ORD 기록
ord-8821263ce0054d48b38ee0adbffc7235
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05693651

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