Phenol → (2,2-Diethoxyethoxy)benzene

HRID 1942440

반응식

HRID 1942440 반응식
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:8]([O:10][CH:11]([O:14][CH2:15][CH3:16])[CH2:12]Cl)[CH3:9].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>[OH-].[Na+].CN(C)C=O>[CH2:8]([O:10][CH:11]([O:14][CH2:15][CH3:16])[CH2:12][O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:9]

참가 물질

7

반응물 4

HCID 996PhenolHCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 121282-Chloro-1,1-diethoxyethane

생성물 1

HCID 96328(2,2-Diethoxyethoxy)benzene

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 14798Sodium Hydroxide용매

실험 절차

0.94 g (10 mmol) of phenol, 1.52 g (10 mmol) of chloroacetaldehyde diethyl acetal, 2.77 g (20 mmol) of potassium carbonate, 500 mg of potassium iodide and 5 ml of dimethylformamide were heated for 1 hour at 175° C. under microwave conditions. The mixture was then diluted with 2M aqueous sodium hydroxide solution and extracted with dichloromethane. The organic layer was dried with sodium sulfate and the solvent evaporated in vacuum. The crude product was obtained in almost quantitative yield.

후처리

  1. extractionextracted with dichloromethane
  2. dry with materialThe organic layer was dried with sodium sulfate
  3. customthe solvent evaporated in vacuum

출처 및 근거

ORD 기록
ord-907d57b1e0434595b23a759968da1805
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389555B2

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