Sodium Fluoride → Methyl 1-chloro-2-fluoro-1-cyclopropanecarboxylate

HRID 1956828노트

반응식

HRID 1956828 반응식
[Cl:1][C:2]1([C:8]([O:10][CH3:11])=[O:9])[CH2:4][CH:3]1C(O)=O.[OH-].[Na+].[Na].[F-:15].[Na+]>O>[Cl:1][C:2]1([C:8]([O:10][CH3:11])=[O:9])[CH2:4][CH:3]1[F:15]

참가 물질

6

반응물 4

HCID 5235Sodium FluorideHCID 14798Sodium HydroxideHCID 5360545SodiumHCID 223713122-Chloro-2-methoxycarbonyl-1-cyclopropanecarboxylic acid

생성물 1

HCID 22371313Methyl 1-chloro-2-fluoro-1-cyclopropanecarboxylate수율 79.1%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

To 111 g of 2-chloro-2-methoxycarbonyl-1-cyclopropanecarboxylic acid was added 200 ml of water. Further, a solution of 24.87 g of sodium hydroxide dissolved in 300 ml of water was added thereto under ice-cooling and stirring to thereby give sodium salt. To this aqueous solution was added 52.25 g of sodium fluoride. Next, 1.3 equivalents, to carboxylic acid, of 10% (v/v) fluorine gas (diluted with nitrogen: 600 ml/min) was bubbled into this solution under ice-cooling and stirring. After the completion of the bubbling, the pH value of the reaction mixture was regulated to 8 to 9 by adding a 1N aqueous solution of sodium hydroxide. Then it was extracted with two 250 ml portions of dichloromethane. The organic layer was collected and dried over sodium sulfate. After evaporating the solvent under reduced pressure, 75 g of the title compound was obtained in the form of a crude product (cis:trans=3:2). After adjusting pH value of the separated aqueous layer to 2 to 3 with hydrochloric acid, it was extracted with two 100 ml portions of dichloromethane. Thus 23.1 g of the starting compound was recovered. After distilling the crude reaction product, the total yield of the cis- and trans-compounds was 76.4% (calculated by excluding the recovered starting compound). The analytical data of the title compound are as follows.

후처리

  1. additionwas added
  2. temperatureunder ice-cooling
  3. customNext, 1.3 equivalents, to carboxylic acid, of 10% (v/v) fluorine gas (diluted with nitrogen: 600 ml/min) was bubbled into this solution under ice-
  4. temperaturecooling
  5. additionby adding a 1N aqueous solution of sodium hydroxide
  6. extractionThen it was extracted with two 250 ml portions of dichloromethane
  7. customThe organic layer was collected
  8. dry with materialdried over sodium sulfate
  9. customAfter evaporating the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-10ab720312434b6da7025b722b84eefd
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05780669

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