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Hydrochloric Acid → Methyl alpha-[4-(3-tert.butylphenoxy)-6-dimethylamino-pyrimidin-5-yl]-beta-methoxyacrylate

HRID 1957167
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HRID 1957167 반응식
[C:1]([C:5]1[CH:6]=[C:7]([CH:23]=[CH:24][CH:25]=1)[O:8][C:9]1[C:14]([CH2:15][C:16]([O:18][CH3:19])=[O:17])=[C:13]([N:20]([CH3:22])[CH3:21])[N:12]=[CH:11][N:10]=1)([CH3:4])([CH3:3])[CH3:2].[H-].[Na+].Cl.[C:29](=[O:32])(O)[O-].[Na+].S(OC)(O[CH3:38])(=O)=O>COCCOC.C(OC)=O.[Cl-].[Na+].O.CCCCCC.C(OCC)(=O)C.CCOCC>[C:1]([C:5]1[CH:6]=[C:7]([CH:23]=[CH:24][CH:25]=1)[O:8][C:9]1[C:14]([C:15](=[CH:38][O:32][CH3:29])[C:16]([O:18][CH3:19])=[O:17])=[C:13]([N:20]([CH3:22])[CH3:21])[N:12]=[CH:11][N:10]=1)([CH3:4])([CH3:2])[CH3:3]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

11

반응물 5

HCID 313Hydrochloric AcidHCID 6497Dimethyl SulfateHCID 24758Sodium hydrideHCID 516892Sodium BicarbonateHCID 19069025Methyl 4-(3-tert.butylphenoxy)-6-dimethylamino-pyrimidin-5-yl-acetate

생성물 1

HCID 67742283Methyl alpha-[4-(3-tert.butylphenoxy)-6-dimethylamino-pyrimidin-5-yl]-beta-methoxyacrylate

시약·촉매·용매 5

HCID 3283Diethyl Ether용매HCID 7865Methyl formate용매HCID 80711,2-Dimethoxyethane용매HCID 21226206Ethyl acetate hexane용매HCID 57417360Sodium chloride; water용매

실험 절차

Methyl 4-(3-tert.butylphenoxy)-6-dimethylamino-pyrimidin-5-yl-acetate (10.0 g, 29 mmol) is dissolved in a mixture of 1,2-dimethoxyethane (60 ml) and methyl formate (20 ml). Sodium hydride (1.7 g, 80% in oil, 58 mmol) is added in one portion, the temperature being kept at room temperature. After 5 hours the reaction mixture is carefully acidified with hydrochloric acid. After stirring for 1 hour at +5° C. the mixture is neutralized with solid sodium bicarbonat. The intermediate product is extracted with ether and worked up in the usual way. The resulting oil is stirred in dimethylformamide (20 ml) and dimethyl sulfate (4.7 ml, 50 mmol) for 2 hours at room temperature. Dilution with ether washing with brine and chromatography on silicagel (eluant:hexane/ethyl acetate 1:1) gives the methyl α-[4-(3-tert.butylphenoxy)-6-dimethylamino-pyrimidin-5-yl]-β-methoxyacrylate as a single isomer (5.5 g).

후처리

  1. custombeing kept at room temperature
  2. extractionThe intermediate product is extracted with ether
  3. stirringThe resulting oil is stirred in dimethylformamide (20 ml)

출처 및 근거

ORD 기록
ord-674935cd3e5a408eb6377b792fc1ae70
출처 데이터셋
uspto-grants-1998_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05783580

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