1-Bromopropane → 3-Cyclopropyl-7-propylxanthine

HRID 2032

반응식

HRID 2032 반응식
[CH:1]1([N:4]2[C:12]3[N:11]=[CH:10][NH:9][C:8]=3[C:7](=[O:13])[NH:6][C:5]2=[O:14])[CH2:3][CH2:2]1.[H-].[Na+].[H][H].Br[CH2:20][CH2:21][CH3:22]>CN(C)C=O>[CH:1]1([N:4]2[C:12]3[N:11]=[CH:10][N:9]([CH2:20][CH2:21][CH3:22])[C:8]=3[C:7](=[O:13])[NH:6][C:5]2=[O:14])[CH2:3][CH2:2]1

참가 물질

6

반응물 4

HCID 78401-BromopropaneHCID 24758Sodium hydrideHCID 30589961H-Purine-2,6-dione, 3,7-dihydro-3-cyclopropyl-HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 196892703-Cyclopropyl-7-propylxanthine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
60 °C

실험 절차

9.6 g (0.05 mol) of 3-cyclopropylxanthine were suspended in 150 ml of dimethylformamide and slowly deprotonated using 1.45 g (0.06 mol) of sodium hydride. When evolution of hydrogen was at an end, the solution was heated to 60° C. and treated dropwise with 6.77 g (0.055 mol) of bromopropane. After stirring at 70° C. for 3 hours, the solution was filtered, the dimethylformamide was evaporated under reduced pressure and the residue was crystallized from diisopropyl ether.

후처리

  1. filtrationthe solution was filtered
  2. customthe dimethylformamide was evaporated under reduced pressure
  3. customthe residue was crystallized from diisopropyl ether

출처 및 근거

ORD 기록
ord-8e167d88150f459d95e6145c9ec1c182
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728686

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