Isobutyraldehyde → HCID 14849775, 화합물

HRID 2050573노트

반응식

HRID 2050573 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=O)=[CH:4][CH:3]=1.C([O-])(=O)C.[NH4+:22].[CH:23](=O)[CH:24]([CH3:26])[CH3:25].[OH-].[NH4+:29]>C(O)(=O)C.C(OC(=O)C)(=O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:29][C:23]([CH:24]([CH3:26])[CH3:25])=[N:22][C:9]=2[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1

참가 물질

7

반응물 4

HCID 6561IsobutyraldehydeHCID 14923Ammonium HydroxideHCID 517165Ammonium AcetateHCID 36253104-Fluorobenzil

생성물 1

HCID 14849775HCID 14849775, 화합물

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 7918Acetic Anhydride용매

실험 절차

To a stirred solution of 1-(4-fluorophenyl)-2-phenylethan-1,2-dione (1.0 g) in acetic acid (25 ml) and acetic anhydride (3 ml) containing ammonium acetate (5.0 g) was added isobutyraldehyde (0.5 g) and the reaction mixture was warmed to 110° for 2 h. The mixture was poured into aqueous ammonium hydroxide at 0° and the deposited solid was collected by filtration, then washed sequentially with ether and water then dried in vacuo to afford the title compound (1.09 g), λmax (EtOH) 252 (9550) and 287.8 nm (ε11,870).

후처리

  1. temperaturethe reaction mixture was warmed to 110° for 2 h
  2. filtrationthe deposited solid was collected by filtration
  3. washwashed sequentially with ether and water
  4. customthen dried in vacuo

출처 및 근거

ORD 기록
ord-4e97bd7cbcac4d58ae8051b1bf1b0e6b
출처 데이터셋
uspto-grants-1991_05
특허 번호
US05013749

반응 노트

불러오는 중…