Cyclohexanol → Cyclohexoxyacetic acid

HRID 2050659

반응식

HRID 2050659 반응식
[CH:1]1([OH:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH2:9][C:10]([O-:12])=[O:11].[Na+]>C1COCC1.CS(C)=O>[CH:1]1([O:7][CH2:9][C:10]([OH:12])=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 7966CyclohexanolHCID 23665759Sodium chloroacetate

생성물 1

HCID 191994Cyclohexoxyacetic acid수율 83.1%

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
25 °C

실험 절차

A solution of cyclohexanol (1.75 g, 17.5 mmol) in THF was added, and the mixture was warmed to 25° C. for 1 hour. The THF was removed by distillation under vacuum, and a solution of sodium chloroacetate (2.5 g, 22 mmol) in DMSO (50 ml) was added. The reaction mixture was treated as in Example 3 and 2.3 g of product (83% yield) was obtained as a colorless oil.

후처리

  1. customThe THF was removed by distillation under vacuum
  2. additionThe reaction mixture was treated as in Example 3

출처 및 근거

ORD 기록
ord-99afaf4f76f64cd1a8deeac02b9f6403
출처 데이터셋
uspto-grants-1991_05
특허 번호
US05013864

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