4-Methylmorpholine → (2-(Trifluoromethyl)pyrimidin-5-yl)methanol

HRID 2062127노트

반응식

HRID 2062127 반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[N:8]=[CH:7][C:6]([C:9](O)=[O:10])=[CH:5][N:4]=1.CN1CCOCC1.C(OC(Cl)=O)C(C)C.[BH4-].[Na+].[Na].C(C(C(C([O-])=O)O)O)([O-])=O.[K+].[K+]>C(OCC)C>[F:13][C:2]([F:1])([F:12])[C:3]1[N:4]=[CH:5][C:6]([CH2:9][OH:10])=[CH:7][N:8]=1

참가 물질

8

반응물 6

HCID 79724-MethylmorpholineHCID 62365Isobutyl chloroformateHCID 4311764Sodium borohydrideHCID 5360545SodiumHCID 6100505Dipotassium 2,3-dihydroxybutanedioateHCID 105838892-(trifluoromethyl)pyrimidine-5-carboxylic Acid

생성물 1

HCID 24903629(2-(Trifluoromethyl)pyrimidin-5-yl)methanol수율 48.5%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To 0.2 g of 2-trifluoromethyl-pyrimidine-5-carboxylic acid 2 mL of diethyl ether were added, and the solution was cooled in ice-water bath to 0° C. Then 0.126 mL of N-methylmorpholine were added, followed by 0.135 mL of isobutyl-chloroformate. The reaction was left stirring for one hour at room temperature. The yellow solid formed was filtered and washed with diethyl ether. To the filtrate, 0.115 g (3.12 mmol) of sodium borohydride was then added at 0° C. and left stirring at that temperature for one hour. 5 mL of a saturated aqueous solution of sodium and potassium tartrate were then added and the mixture was extracted twice with ethyl acetate, dried with magnesium sulphate, filtered and concentrated to afford 0.09 g of (2-Trifluoromethyl-pyrimidin-5-yl)-methanol as an oil, which was used without further purification.

후처리

  1. waitThe reaction was left
  2. customThe yellow solid formed
  3. filtrationwas filtered
  4. washwashed with diethyl ether
  5. waitleft
  6. stirringstirring at that temperature for one hour
  7. extractionthe mixture was extracted twice with ethyl acetate
  8. dry with materialdried with magnesium sulphate
  9. filtrationfiltered
  10. concentrationconcentrated

출처 및 근거

ORD 기록
ord-93b156c8940c4e84aa1f2ce0b2adbd42
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08283479B2

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