Water → 2-Amino-3-(2-methyl-6-methoxycarbonylaminobenzylamino)pyridine

HRID 2073803

반응식

HRID 2073803 반응식
[NH2:1][C:2]1[C:7]([N:8]=[CH:9][C:10]2[C:15]([NH:16][C:17]([O:19][CH3:20])=[O:18])=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:21])=[CH:6][CH:5]=[CH:4][N:3]=1.[BH4-].[Na+].O>CO.C(Cl)(Cl)Cl>[NH2:1][C:2]1[C:7]([NH:8][CH2:9][C:10]2[C:15]([NH:16][C:17]([O:19][CH3:20])=[O:18])=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:21])=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

6

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 144998242-Amino-3-(2-methyl-6-methoxycarbonylaminobenzylideneamino)pyridine

생성물 1

HCID 144998172-Amino-3-(2-methyl-6-methoxycarbonylaminobenzylamino)pyridine수율 94.1%

시약·촉매·용매 2

HCID 887Methanol용매HCID 6212Chloroform용매

실험 절차

To a solution of 2-amino-3-(2-methyl-6-methoxycarbonylaminobenzylideneamino)pyridine (229 mg) in methanol (4.6 ml) and chloroform (4.6 ml) was added sodium borohydride (200 mg) and the mixture was stirred for 3.5 hours at room temperature. After water was added, organic layer was separated and dried over magnesium chloride. The solvent was evaporated under reduced pressure. The residue was triturated with diethyl ether to give 2-amino-3-(2-methyl-6-methoxycarbonylaminobenzylamino)pyridine (217 mg).

후처리

  1. customorganic layer was separated
  2. dry with materialdried over magnesium chloride
  3. customThe solvent was evaporated under reduced pressure
  4. customThe residue was triturated with diethyl ether

출처 및 근거

ORD 기록
ord-7b8224e273b24a24b6518a7792f389bf
출처 데이터셋
uspto-grants-1990_04
특허 번호
US04920129

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