Hydrochloric Acid → 4-Biphenylyl benzoate

HRID 2082109노트

반응식

HRID 2082109 반응식
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:13][CH:12]=1.Cl.O>N1C=CC=CC=1>[C:1]([O:10][C:11]1[CH:12]=[CH:13][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:15][CH:16]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 71034-HydroxybiphenylHCID 7412Benzoyl chloride

생성물 1

HCID 2317434-Biphenylyl benzoate수율 94%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

128 ml benzoyl chloride is dripped into a solution of 170 g 4-hydroxybiphenyl in 500 ml pyridine, at 20° C.; subsequently, the reaction mixture is heated under reflux for 30 min. After cooling, the reaction mixture is mixed with a solution of 500 ml concentrated hydrochloric acid and 750 ml water. The remaining precipitate is filtered off, washed neutral with water, dried and recrystallized from n-butanol (melting point: 150° C.); yield: 94%.

후처리

  1. temperaturesubsequently, the reaction mixture is heated
  2. temperatureunder reflux for 30 min
  3. temperatureAfter cooling
  4. filtrationThe remaining precipitate is filtered off
  5. washwashed neutral with water
  6. customdried
  7. customrecrystallized from n-butanol (melting point: 150° C.)

출처 및 근거

ORD 기록
ord-0c10c08e9eb6412ab234c4568d03deef
출처 데이터셋
uspto-grants-1993_02
특허 번호
US05187237

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