Hydrochloric Acid → 1-(4'-Methoxy(1,1'-biphenyl)-2-yl)ethan-1-one

HRID 2101231노트

반응식

HRID 2101231 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[Al+3].[Cl-].[Cl-].[Cl-].[C:19](Cl)(=[O:21])[CH3:20].Cl>O.C(=S)=S>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=2[C:19](=[O:21])[CH3:20])=[CH:5][CH:4]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 119434-MethoxybiphenylHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 43213891-(4'-Methoxy(1,1'-biphenyl)-2-yl)ethan-1-one

시약·촉매·용매 2

HCID 962Water용매HCID 6348Carbon Disulfide용매

실험 절차

The 4′-methoxybiphenyl (0.05 mol) and AlCl3 (0.06 mol) were dissolved in boiling CS2 (60 mL) with stirring. Acetyl chloride (0.1 mol) was added dropwise and reflux continued for 1 hour. The mixture was poured onto crushed ice (150 mL) containing water (50 mL) and HCl (50 mL). The organic phase was separated and the CS2 removed by distillation. The residue was recrystallised from aqueous isopropanol to give the title compound. δC (CDCl3, 62.9 MHz): 26.6, 55.4, 114.4, 126.6, 128.4, 129.0, 132.2, 135.3, 145.4, 159.9 and 198.0

후처리

  1. temperaturereflux
  2. additionThe mixture was poured
  3. customThe organic phase was separated
  4. customthe CS2 removed by distillation
  5. customThe residue was recrystallised from aqueous isopropanol

출처 및 근거

ORD 기록
ord-28c7f26a8ccf4af7a49217cf1aeb0d75
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07572825B2

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