Hydrochloric Acid → N-(3-Cyano-4,5,6,7-tetrahydrobenzo(b)thien-2-yl)benzamide

HRID 21366

반응식

HRID 21366 반응식
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:10][C:11]1[S:15][C:14]2[CH2:16][CH2:17][CH2:18][CH2:19][C:13]=2[C:12]=1[C:20]#[N:21].Cl>N1C=CC=CC=1>[C:1]([NH:10][C:11]1[S:15][C:14]2[CH2:16][CH2:17][CH2:18][CH2:19][C:13]=2[C:12]=1[C:20]#[N:21])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 7412Benzoyl chlorideHCID 783822-Amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carbonitrile

생성물 1

HCID 290221N-(3-Cyano-4,5,6,7-tetrahydrobenzo(b)thien-2-yl)benzamide수율 97%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

4.7 ml (40 mmol) of benzoyl chloride were added to a solution of 5.34 g (30 mmol) of 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene in 50 ml of pyridine. Stirring was carried out for 2 hours at 80° C. after which 150 ml of 10 mol % aqueous hydrochloric acid were added to the mixture. The solid formed was isolated in a conventional manner. Yield: 97%; mp.: 168°-170° C.

후처리

  1. customThe solid formed
  2. customwas isolated in a conventional manner

출처 및 근거

ORD 기록
ord-c687d545fb614a2799fe1a2c2fe90189
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05422335

연결된 노트

불러오는 중…