Hydrochloric Acid → 4-(Isopropoxymethyl)-pyridine

HRID 21373

반응식

HRID 21373 반응식
[Na].Cl.Cl[CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1.Cl.[CH:12]([OH:15])([CH3:14])[CH3:13]>>[CH:12]([O:15][CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)([CH3:14])[CH3:13]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 745704-(Chloromethyl)pyridinium chlorideHCID 5360545Sodium

생성물 1

HCID 144422044-(Isopropoxymethyl)-pyridine

실험 절차

3.4 g of sodium are dissolved in 120 ml of isopropanol and 11 g (0.067 mol) of 4-chloromethylpyridine-hydrochloride are added. The reaction mixture is refluxed for 10 hours under nitrogen, with stirring, then after cooling it is made weakly acidic with dilute hydrochloric acid and concentrated by evaporation under reduced pressure. The residue is made alkaline with 40% potassium carbonate solution and extracted with ether. After drying with anhydrous sodium sulphate the organic phase is concentrated by evaporation. The crude product is then distilled.

후처리

  1. temperatureThe reaction mixture is refluxed for 10 hours under nitrogen
  2. temperatureafter cooling it
  3. concentrationconcentrated by evaporation under reduced pressure
  4. extractionextracted with ether
  5. dry with materialAfter drying with anhydrous sodium sulphate the organic phase
  6. concentrationis concentrated by evaporation
  7. distillationThe crude product is then distilled

출처 및 근거

ORD 기록
ord-9964c7de6933407d9c2220728e01fc8c
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05422353

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