Ammonium Acetate → 1-(2',5'-Difluoro-1,1'-biphenyl-2-yl)ethylamine

HRID 2181900

반응식

HRID 2181900 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15](=O)[CH3:16].C([O-])(=O)C.[NH4+].C([BH3-])#[N:24].[Na+]>CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH:15]([NH2:24])[CH3:16]

참가 물질

5

반응물 3

HCID 517165Ammonium AcetateHCID 5003444Sodium cyanoborohydrideHCID 224823961-(2',5'-Difluoro-1,1'-biphenyl-2-yl)ethanone

생성물 1

HCID 224822831-(2',5'-Difluoro-1,1'-biphenyl-2-yl)ethylamine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The title compound was prepared from 1-(2′,5′-difluoro-1,1′-biphenyl-2-yl)ethanone (2.0 g, 8.6 mmol), anhydrous methanol (100 mL), ammonium acetate (13.3 g, 172 mmol), and sodium cyanoborohydride (1.08 g, 17.2 mmol) according to the procedure and in the same manner as described in Example 105, step b;

출처 및 근거

ORD 기록
ord-9465f3c683de4a22b3818456430bdbc4
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06894061B2

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