Dichloromethane → 6-Ethylpyridin-2-amine

HRID 2197704

반응식

HRID 2197704 반응식
C(OC(=O)C(=C[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[N:14]=1)C(OCC)=O)C.Cl.NO.[OH-].[Na+].[CH2:26](Cl)Cl>CCO.O>[CH2:19]([C:15]1[N:14]=[C:13]([NH2:12])[CH:18]=[CH:17][CH:16]=1)[CH3:26]

참가 물질

7

반응물 4

HCID 6344DichloromethaneHCID 14798Sodium HydroxideHCID 83264Diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonateHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 890216-Ethylpyridin-2-amine

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

The product from Example 1a (4.93 g, 0.025 mol) was dissolved in a mixture of EtOH (80 mL) and water (30 mL). To this was added hydroxylamine hydrochloride (8.6 g, 0.123 mol) and the resulting mixture heated to 100° C. for 8 h. The reaction mixture was poured into dilute sodium hydroxide solution and the crude product isolated by extraction with CH2Cl2 and dried over MgSO4 filtered and concentrated under vacuum giving the title compound. The material was used as isolated.

후처리

  1. dry with materialdried over MgSO4
  2. filtrationfiltered
  3. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-1e80fa44fa2048f6874f4c4088eb0c94
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338605B2

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