Hydrochloric Acid → 4-Ethoxyphenylthiourea

HRID 224751

반응식

HRID 224751 반응식
Cl.[CH3:2][CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([NH2:11])=[CH:9][CH:10]=1.[C:12]([SH:14])#[N:13].N.[Na]>>[CH2:3]([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([NH2:13])=[S:14])=[CH:7][CH:6]=1)[CH3:2]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 90764-EthoxyanilineHCID 5360545SodiumHCID 13417437Amthio

생성물 1

HCID 8535694-Ethoxyphenylthiourea

실험 절차

750 Parts of a 30% aqueous hydrochloric acid are placed into a reaction vessel, whereupon 822 parts of p-phenetidine, 479 parts of ammonium rhodanide and 31.2 parts of sodium hydrogenosulfite are introduced successively, while stirring. The reaction mixture is stirred for 15 hours at 80° C., thereafter for 8 hours at 95° C., and subsequently the precipitate having been formed is filtered off with suction, while hot, and washed with hot water until neutral. The dried product gives a yield of 1129 parts (corresponding to 96.0% of the theory) of p-ethoxyphenyl thiourea of the formula ##STR4## which product has a melting point of from 167° to 168° C.

후처리

  1. additionare introduced successively
  2. stirringThe reaction mixture is stirred for 15 hours at 80° C.
  3. customsubsequently the precipitate having been formed
  4. filtrationis filtered off with suction
  5. washwhile hot, and washed with hot water until neutral

출처 및 근거

ORD 기록
ord-755737ba55854367b5dfd42f254cf462
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04234513

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