Hydrazine hydrate (1:1) → Indole, 3-(2-amino-2-methylpropyl)-5-bromo-

HRID 224897

반응식

HRID 224897 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][C:12]([CH3:17])([N+:14]([O-])=O)[CH3:13].O.NN>[Ni+2]>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][C:12]([CH3:17])([CH3:13])[NH2:14]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 126196615-Bromo-3-(2-methyl-2-nitropropyl)indole

생성물 1

HCID 13259Indole, 3-(2-amino-2-methylpropyl)-5-bromo-

시약·촉매·용매 1

HCID 934Nickel cation촉매

실험 절차

5-Bromo-3-(2-methyl-2-nitropropyl)indole, 5.9 g. was reduced with Raney nichel and hydrazine hydrate according to the method of Procedure 67D. The crude product was purified by dissolving in 200 ml. of dilute hydrochloric acid, treatment with activated charcoal, filtering, and basification of the filtrate with 10% aqueous sodium hydroxide. Yield 3.8 g. of white powder, m.p. 150°-155° C.

후처리

  1. customThe crude product was purified
  2. dissolutionby dissolving in 200 ml
  3. filtrationof dilute hydrochloric acid, treatment with activated charcoal, filtering

출처 및 근거

ORD 기록
ord-1e15576f9e24402ea73d6f066ceafe14
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04234595

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