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Hydrochloric Acid → 3-[5-(3,5-Diisobutoxybenzoyl)-2-isobutoxyphenyl]propanoic acid

HRID 2249630
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HRID 2249630 반응식
[CH2:1]([O:5][C:6]1[CH:7]=[C:8]([CH:29]=[C:30]([O:32][CH2:33][CH:34]([CH3:36])[CH3:35])[CH:31]=1)[C:9]([C:11]1[CH:12]=[CH:13][C:14]([O:24][CH2:25][CH:26]([CH3:28])[CH3:27])=[C:15]([CH2:17][CH2:18][C:19]([O:21]CC)=[O:20])[CH:16]=1)=[O:10])[CH:2]([CH3:4])[CH3:3].[OH-].[Na+].C(Cl)(Cl)Cl.Cl>C(O)C.O>[CH2:33]([O:32][C:30]1[CH:29]=[C:8]([CH:7]=[C:6]([O:5][CH2:1][CH:2]([CH3:4])[CH3:3])[CH:31]=1)[C:9]([C:11]1[CH:12]=[CH:13][C:14]([O:24][CH2:25][CH:26]([CH3:27])[CH3:28])=[C:15]([CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH:16]=1)=[O:10])[CH:34]([CH3:36])[CH3:35]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 6212ChloroformHCID 14798Sodium HydroxideHCID 17816456Ethyl 3-[5-(3,5-diisobutoxybenzoyl)-2-isobutoxyphenyl]propanoate

생성물 1

HCID 576844023-[5-(3,5-Diisobutoxybenzoyl)-2-isobutoxyphenyl]propanoic acid수율 93.2%

시약·촉매·용매 2

HCID 702
Ethanol
용매
HCID 962Water용매

실험 절차

In 9 ml of ethanol is dissolved 1.74 g of ethyl 3-[5-(3,5-diisobutoxybenzoyl)-2-isobutoxyphenyl]-propanoate. After adding 2 ml of 5 mol/L solution of sodium hydroxide, the mixture thus obtained is stirred at ambient temperature for one hour. Chloroform and water are added to the reaction mixture, pH is adjusted to 2 with 6 mol/L hydrochloric acid, and the organic layer is separated. The organic layer is successively washed with water and saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate, and the solvent is distilled off under reduced pressure. Thus, 1.53 g of 3-[5-(3,5-diisobutoxybenzoyl)-2-isobutoxyphenyl]propanoic acid is obtained as a white solid product.

후처리

  1. customthe mixture thus obtained
  2. customthe organic layer is separated
  3. washThe organic layer is successively washed with water and saturated aqueous solution of sodium chloride
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationthe solvent is distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-37b51e593b7c4ddd8bae7b2d0bf1b3fd
출처 데이터셋
uspto-grants-2008_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07314888B1

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